VirB8_Atu2      -------------------------------MKGSEY-----------------ALLVAR
VirB8_Atu1      -------------------------------------------------------MLVAR
VirB8_Ret       ---------------------IFTRVWRMDSMKGSDY-----------------ALLVGR
VirB8_Bsu       ----------------------------MFGRKQSPQ----------------KSVKNGQ
VirB8_Bab       ----------------------------MFGRKQSPQ----------------KSVKNGQ
PtlE_Bpe        ------MGHPGHRPRHARRLRPERAARLAVSRWQAPDSHQHRRPGARIVMPDPRPLTPDQ
TrwG_Eco        ----------------------------MSKKQPKP---------------------VKA
TraE_Eco        ----------------------------MKANKKTG---------------------LTR
ComB1_Hpy1      ---------------------------MKEKPFNSEQM---------------AFLEELL
ComB1_Hpy2      ---------------------------MREKPFNSEQL---------------IYLEELL
Orf_Hpy         MSKRSEVLEQFHGGLKNLELQTKRRMGLWGDPKENEEQ---------------TLFLEEI
TrbF_RK2        ------MSFADTIKGLIFKK-----KPATAAAAATPAATG-------------------P
TrbF_Eae        ------MSIADTLKGLIFKKPANSAEPRDPRRSKEPLAGGR----------------RAG
TrbF_Atu        -----------------------------MAGTTPP------------------------
TrbF_Rsp        -----------------------------MAANRAP------------------------
VirB8_Bhe       ------------------------------------------------------------
Orf_Rpr         ---------------------MNNIFGFFKSSNNTQS-------------------ASGG
LvhB8_Lpn       ---------------------------------------------------------MSK
VirB8_Rpr       ------------------------MIELKHNKLDYN----------------LVIMDQLT
                                                                            

VirB8_Atu2      ETLAEHYKEVEAFQTARAKSARR-------------------------------------
VirB8_Atu1      ESLAEHYKEVEAFQTARAKSARR-------------------------------------
VirB8_Ret       EKLAEHYKEVEAFQTARAKSARR-------------------------------------
VirB8_Bsu       GNAPSVYDEALNWEAAHVRLVEK-------------------------------------
VirB8_Bab       GNAPSVYDEALNWEAAHVRLVEK-------------------------------------
PtlE_Bpe        THGRGHAEAAVDWEASRLYRLAQ-------------------------------------
TrwG_Eco        EQLKSYYEESRGLERDLIGEFVK-------------------------------------
TraE_Eco        EAIKEFNESRKGLEVDLMDEVLK-------------------------------------
ComB1_Hpy1      SHQEKHLESKLSGFSVNDLDMQS-------------------------------------
ComB1_Hpy2      SHQEKHLENKLSGFSVSDLDMQS-------------------------------------
Orf_Hpy         ENELKQLENKENLKADNNTEFKEENQDTKENQPNDLFSLPLPTQTTINGIKEFVEEPVIE
TrbF_RK2        QTDNPYLTARRTWNDHVGSVVSQ-------------------------------------
TrbF_Eae        EAENPYLAARRTWNDHVGGVVSQ-------------------------------------
TrbF_Atu        --DNPYIAARNEWNERYGSYVKA-------------------------------------
TrbF_Rsp        --ENPYLAARQEWTERYGSYVRA-------------------------------------
VirB8_Bhe       ---MHGMRQR--------------------------------------------------
Orf_Rpr         KQNQENIKSANPLKISQNWYEER-------------------------------------
LvhB8_Lpn       TNWNDYFKRARSWADDQFGRIEQ-------------------------------------
VirB8_Rpr       NAIKEYIKSGEYFIDARKWYNFK-------------------------------------
                                                                            

VirB8_Atu2      ---------------------------------------------------LSKVIAAVA
VirB8_Atu1      ---------------------------------------------------LSKIIAAVA
VirB8_Ret       ---------------------------------------------------LSRVAAVVA
VirB8_Bsu       ---------------------------------------------------SERRAWKIA
VirB8_Bab       ---------------------------------------------------SERRAWKIA
PtlE_Bpe        ---------------------------------------------------SERRAWTVA
TrwG_Eco        ---------------------------------------------------SRKTAWRVA
TraE_Eco        ---------------------------------------------------SRRTAWMVA
ComB1_Hpy1      -----------------------------------------------VFRLERNRLKIAY
ComB1_Hpy2      -----------------------------------------------VFRLERNRLKIAY
Orf_Hpy         TEKKETSQNEPIQEKKERIFKNFFSRIGFDKSIAPTMLFEEVRDASVIYHLEKKLGDYIF
TrbF_RK2        -----------------------------------------------------KQTWQVV
TrbF_Eae        -----------------------------------------------------RQTWQVI
TrbF_Atu        -----------------------------------------------------AAAWRIV
TrbF_Rsp        -----------------------------------------------------AAAWRTV
VirB8_Bhe       ----------------------------------------------------MRIAMALT
Orf_Rpr         ------------------------------------------------SDKLIVQRNLLI
LvhB8_Lpn       ----------------------------------------------------SRNRYQAA
VirB8_Rpr       ------------------------------------------------YILPLSHRSFLF
                                                                            

VirB8_Atu2      TIAVLGNVAQAFTIAT---MVPLIRLVPVYLWIRPD-GTVDSEVSVSRLPATQEEAVVNA
VirB8_Atu1      AIAILGNVAQAFAIAT---MVPLSRLVPVYLWIRPD-GTVDSEVSISRLPATQEEAVVNA
VirB8_Ret       AVATLGNVAQAFTIAT---MVPLTRLVPVYLWIRPD-GTVDSEVSVSRLPATQEKAVVNA
VirB8_Bsu       GAFGTITVLLGIGIAG---MLPLKQHVPYLVRVNAQTGAPDILTSLDEKSVSYDTVMDKY
VirB8_Bab       GAFGTITVLLGIGIAG---MLPLKQHVPYLVRVNAQTGAPDILTSLDEKSVSYDTVMDKY
PtlE_Bpe        WAALAVTALSLIAIAT---MLPLKTTIPYLIEVEKSSGAASVVTQFEPRDFTPDTLMNQY
TrwG_Eco        TASGLFGLLGMVCG---IVGFSQPAPAPLVLRVDNATGAVDVVTTLREHESSYGEVVDTY
TraE_Eco        TGSAVVTVFALSLVGYVVHKYSQPIPAHLLT-LNEATHEVQQVKLTRDQTS-YGDEIDKF
ComB1_Hpy1      RLLGLMSFIALVLAIVLISILPLQKTEHHFVDFLNQ-DKHYAIIQRADKSISSNEALARS
ComB1_Hpy2      KLLGLMSFIALILAIVLISLLPLQKTEHHFVDFLNQ-DKHYAIIQRADKSISSNEALARS
Orf_Hpy         YVACFFFGTTALLIILLTILLPLKQKEPYLVQFSNN-KENFALVQKADSSITANKALIRS
TrbF_RK2        GILSLMIVLAAVGGIIHIGSQSKFVPYVYEVDKLGQTAAVGPMTRASKADPRVIHASVAE
TrbF_Eae        GILSLLIALAGVGGVIHIGSQSKFIPYVVEVDKLGQTVAAGPVQAAGKADPRVIHAAVAD
TrbF_Atu        GITGMTMAVIGFGYALYQSTQVKLIPYIVEVDKLGTAVNAGFPQQIEYADPRVVRATLGS
TrbF_Rsp        GILGLAMAVIGFGYAMYLSTEVKLVPYIVQVDKLGTSVTTGFPEQIEYADVRVVRATLGN
VirB8_Bhe       VLFGLMTIALALAVAA---LTPLKTVEPFVIRVDNSTGIIETVSALKETPNDYDEAITRY
Orf_Rpr         ILIILLTIFMVISTLVIAFVVKSKQFDPFVIQLNSNTGRAAVVEPISSSMLTVDESLTRY
LvhB8_Lpn       FFSAMGLNVVALIVIG--MLAHYQTVVPMLVHHYDN--GVTTVEPMENKLTPINRAQIES
VirB8_Rpr       LTCIIFTLLLTLICLNINILLPIHKKVGYLIKDDSE-KQATITNTKHSTLANPYIAVANI
                                                                            

VirB8_Atu2      SLWEYVRLRESYDADT--AQYAYDLVSNFSAPMVRQNYQQFFNYPNPTSPQVILGKHGRL
VirB8_Atu1      SLWEYVRLRESYDADT--AQYAYDLVSNFSAPTVRQDYQQFFNYPNPSSPQVILGKRGRV
VirB8_Ret       SLWEYVRMRESYTADT--AQYAYDLVSNFSAPAVRQDYQQFFNYPNPGSPQVVVGKRGRL
VirB8_Bsu       WLSQYVIARETYDWYT--LQKDYETVGMLSSPSEGQSYASQFQGDKALDKQYGSNVRTSV
VirB8_Bab       WLSQYVIARETYDWYT--LQKDYETVGMLSSPSEGQSYASQFQGDKALDKQYGSNVRTSV
PtlE_Bpe        WLTRYVAARERYDWHT--IQHDYDYVRLLSAPAVRHDYETSYEAPDAPDRKYGAGTTLAV
TrwG_Eco        WLNQYVLNREAYDYNT--IQMNYDTTALLSAPAVQQDYYKLFDGSNARDRVLGNKARITV
TraE_Eco        WLTQYVIHRESYDFYS--VQVDYTAVALMSTPNVAESYQSKFKGRNGLDKVLGDSETARV
ComB1_Hpy1      LIGAYVLNRESINRID--DKSRYELVRLQSSSKVWQRFEDLIKAQNSIYVQSHLEREVHI
ComB1_Hpy2      LIGAYVLNRESINRID--DKSRYELVRLQSSSKVWQRFEDLIKTQNSIYVQSHLEREVHI
Orf_Hpy         LVGAYVLNRESITHIEQHEKMRQNTIKEQSSNEVWYEFEKLIAHYDSIYTNPLLTRKVKI
TrbF_RK2        FVGDARLVTPDVALQRKAVYRLYAKLGP-NDPATAKMNEWLNGTADASPFARAAVETVST
TrbF_Eae        WMSCARMVSPDVALQRKCVFKAYSMFAP-NDPATPKMNEWLNGTPDSSPFKRAEKEMVSV
TrbF_Atu        FVSNFRSVTPDAVVQKQYIDRTYGLLRT-SDPATEKVNAWFRSN---SPFEKAKTATVAI
TrbF_Rsp        FVTSFRSITPDAAVQKQYIDRTYVLLRT-SDPSTEKINAWFRGN---SPFEKAKTATVAI
VirB8_Bhe       FASKYVRAREGFQLSE--AEHNFRLVSLLSSPEEQSRFAKWYAGNNPESPQNIYQNMIAT
Orf_Rpr         FIKKYITARETYNPVD-FATIARTTVRLFSTSAVYYNYLGYIRNKDFDPTLKYKEDNTTF
LvhB8_Lpn       DIARYIQYRESYDASS--YRAQFELVHLLSNSTVAKEYLQEQDAANTASPIHALGNHIKR
VirB8_Rpr       MLQNYVKQREKYNYDT--LKEQFTFIKNASTSIVYMQFANFMNIDNSLSPVIRYQKLYRR
                                             .                              

VirB8_Atu2      EVEHIASNDVTPGVQQIR------------YKRTLIVDG--KMPMASTWTATVRYEKVT-
VirB8_Atu1      EVEHIASNDVTPSTQQIR------------YKRTLVVDG--KMPVVSTWTATVRYEKVT-
VirB8_Ret       EVEHIASNDVAPGVQEIR------------YKRTLVIDS--KMPVVSTWTATIHYEKVN-
VirB8_Bsu       TIVSIVPNG--KGIGTVR------------FAKTTKRTNETGDGETTHWIATIGYQYVNP
VirB8_Bab       TIVSIVPNG--KGIGTVR------------FAKTTKRTNETGDGETTHWIATIGYQYVNP
PtlE_Bpe        KILSAIDHG--KGVGTVR------------FVRTRRDADGQGAAESSIWVATVAFAYDQP
TrwG_Eco        RVRSIQPNG--RGQATVR------------FTTQQHNSNGTVE-RPQHQIATIGYTYIG-
TraE_Eco        KINSVILDKP-HGVRTIR------------FTTVRRVRTNPVDDQPQRWIAIMGYEYKS-
ComB1_Hpy1      VNIAIYQQDN-NPIASVS------------IAAKLLNENKLVYEKRYKIVLSYLFDTPD-
ComB1_Hpy2      VNIAIYQQDN-NPIASVS------------IAAKLLNENKLVYEKRYKIVLSYLFDTPD-
Orf_Hpy         ANIYLDKD-----LAYID------------IEVSLYHSGELESLKRYKVVMSFEFKKQE-
TrbF_RK2        EITSVIPQT--PDTWQVD------------WVETTRDRQGVVKGQPVRMRALVTVYVVEP
TrbF_Eae        EIKTVIPQT--PDTWQVE------------WVETTRDRQGTLKGQPVTWRALVTTYIAEV
TrbF_Atu        EVNNIVALS--NQSYQVD------------WTEFERDR----RGKETATRRFRGIATVTL
TrbF_Rsp        EVNNIVALS--NQTYQID------------WTEYERDR----KGKEIGTRRFRGIATVTL
VirB8_Bhe       VTIKSISFLS-KDLIQVR------------YYKTVRELND--KENISHWVSILNFSYIN-
Orf_Rpr         LVIKSWSK-----IADDK------------YIVRFSVNETSGSQLVYNKIAVVSYDYVP-
LvhB8_Lpn       EVRIYSINFLDSVLANEKDLHKDHHALAEVVFSLIDTDKTSGKTTSTHYNAMISWRYTN-
VirB8_Rpr       SINIISINNINNNEATVT-------------FESLAQNNTGEILENMLWEARIGFIMDS-
                                                                            

VirB8_Atu2      -SLPGRLRL-TNPGGLVVTSYQTSEDTVSNAGHSEP-------
VirB8_Atu1      -SLPGRLRL-TNPAGLVVTSYQTSEDTVSNVGQGAP-------
VirB8_Ret       -SLPGRLRL-TNPGGLVITSYQTSEDTVSNAGAGEP-------
VirB8_Bsu       SLMSESARL-TNPLGFNVTSYRVDPEMGVVQ------------
VirB8_Bab       SLMSESARL-TNPLGFNVTSYRVDPEMGVVQ------------
PtlE_Bpe        RALTQAQRW-LNPLGFAVTSYRVDAEAGQP-------------
TrwG_Eco        APMRSSDRL-LNPLGFQVTSYRADPEILNN-------------
TraE_Eco        LAMNAEQRY-VNPLGFRVTSYRVNPEVN---------------
ComB1_Hpy1      --FDYASMP-KNPTGFKITRYSITEIAPTNRND----------
ComB1_Hpy2      --FDYASMP-KNPTGFKITRYSITEIAPTNRGD----------
Orf_Hpy         --INFDSMS-LNPTGFMVTSYDVTEIAIVNYPTAKAIGLFLAS
TrbF_RK2        TADTKEEQLRNNPAGIYVRDFSWSRL-----------------
TrbF_Eae        TPNTTDEQLRNNPLSIYVRDYSWSRIQ----------------
TrbF_Atu        TPPQDEGVIRLNPIGLYLRDFDWTAQL----------------
TrbF_Rsp        TAPQDEATIRLNPIGLYVRDFDWTAQL----------------
VirB8_Bhe       AQISTQDRL-INPLGFQVSEYRSDPEVIQ--------------
Orf_Rpr         -MQLTDSELDINPVGFQVNGYRVDDDNS---------------
LvhB8_Lpn       -PPDSPETRWKNWDGFEVTRYSRQTRLMEAQA-----------
VirB8_Rpr       ---ISTSTLQDMTFNFTVTSYKLKLLRNKNQQ-----------
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