Figure S11



             8(G-------TMS-------I)26
        1--------10--------20--------30--------40--------50--------60--------70--------80--------90--------100-------110-------120
I:
Pae5    -VIGLAIGFGAQSLVADLITGLFIIIEDSLSIDDYVDVG------------------------GHLGTVEGLTIRTVRLRDLD-----------GVVHTIPFSEIKSIKNYSRQFGYAMFRWP
Ssp5    -LLALAISFGAQSLVKDLVDGFLVLAEDQYAIGDVIDVG------------------------FAAGGVENLNLRVTQLRSAG-----------GELVTIPNSAITQVKNLTRSWSRANLSVN
Ssp6    -GVAFVLAFLGRNVVEDMLNGTLILWTDRYAIGDVVQIG------------------------DVFGLVENMNIYITQLRGPE-----------GRLSTIPNGKISVVQNLTKDWSRAEFIVE
Ssp4    -IIGFAVSFGSQNLIKDLIAGISNLMSDAFAINDFVLIG------------------------EFEGVVEDTNLFVTRIRCPN-----------GDLVTIPNGAIGTVCNQTKDWSRVDYSVM
Sme3    -VFGVAIGFGSQTLVKDILSGVFYMMDDAFRVGEYIQSG------------------------SYKGTVESFSIRSVKLRHHR-----------GPVFTVPFGSLGAVQNMSRDWVIDKFMIN
Sme2    -IFGVAIGFGSQTLVKDVLSGVFYMLDDAFRVGEYIQSG------------------------SYKGTVESFSLRSVRLRHHR-----------GPIFTVPFGELGAVQNMSRDWVIDKMTLN
Mlo3    -VVGVAVGFGAQTIVKDVISGVFYLLDDAFRVGEYISSG------------------------SYRGTVESFSLRSVKLRHHR-----------GPLFTIPFGELGAVQNQSRDWVTDKFNVT
Zmo1    -IMGAAIAFGSQSLVKDFITGFFMLVEDAIQVGDWVSTG------------------------GVSGTVEHLSIRTLRVRAVN-----------GDLHIIPFSSVSSIANTGRDFNQIIIRQT
Eco5    -ALGLAISFGSQTLVKDIITGVFIQFENGMNTGDLVTIG------------------------PLTGTVERMSIRSVGVRQDT-----------GAYHIIPWSSITTFANFVRGIGSVVANYD
          .. .:.* .:.:: *.: *      :    .: :  *                           * **  .:    :*              *    :* . :  . *  :          

II:
Sco1    -VVGLAIGFGAQSLVADYLSGLLIMVEDQYGVGDSVDLG------------------------EAVGEVEHVGLRLTHVRDLN-----------GGLWHIRNGEILRVRNDSQEWARAVLDVA 
Sco2    -VAGVAIGFGARNLVTDFLSGVFMILEDQYGVGDSIDAG------------------------VASGEVIEVGLRVTKLRGVD-----------GEIWYVRNGEVKRIGNLSQGWSTAGVDVT
Mtu2    -VLGAALGFGAQRLVQDLLAGFFIIVEKQYGFGDLVELSMVGS------------------PENAAGTVEDVTLRVTKLRSSE-----------GEVFTVPNGNIVKSVNLSKDWARAVVDIP
Dra2    -VLGLAVSFGAQNLFKDLFTGFFILLEDQYGVGDVITINTG----------------------QLSGNVESVNLRVTTLRALD-----------GTVHIVPNGQIQTVSVSSKDWSRVVATVD
         * * *:.***: *. * ::*.::::*.***.** :  .                           * *  * **:* :*  :           * :  : **::      *: *: .   : 

III:
Bha2    -IVGLAIGFGAQGLVSDIVTGFFILLEKQIDVGDYVTAG------------------------GVDGIVEEVGLRTALIRGFD-----------GTLHYIPNRNIANVSNHSRGNMRALVDIS
Bsu2    -IVGLAVGFGAQGLVSDIVTGFFILLEKQLDVGDYITVS------------------------TFDGIVEQVGLRTTQIRSFD-----------ETLHYIPNRNITNVSNHSRGTMQALVDIK
Spn     -IAGVAIGMGAQGFLSDVINGFFILFERQLDVGDEVVLTNG--------------------PITVSGKVVSVGIRTTQLRSEE-----------QALHFVPNRNITVVSNFSRTD--------
Spy     -IAGVAIGLGAQGFLSDVVNGFFILFENQFEVGDNVTIS------------------------DIEGSVFGVGIRTTQIRGFD-----------GTLHFIPNRSITVVSNKSRGNMRALIEIP
Sau     -VVGLAVGFGAQTIVKDVITGFFIIFESQFDVGDYVKINNGG-------------------TTVAEGTVKSIGLRSTRINTIS-----------GELTILPNSSMGEITNYSITNGTAIVKIP
Lla     -ILGVALGFAGRDLVADIINGFFIIVEHQINVGDTVAFAG----------------------LDIEGVVKTVGIRSITVIGAD-----------GATTFIPNRNIAALKNYSYKERTVNLDVP
         : *:*:*:..: :: *::.****:.* *::*** :                             .* *  :*:*:  :   .                :** .:  :.* *           

IV:
Tac1    -FISAVIGLAAQTVLSNIFGGLFISVVRPFNVGDHVIINTWQYGASLPSYPPKYFSRDFMEASMYRGIIFDISMNYTTIVLES-----------GDTVKIPNGIMVQAAITIRK---------
Tvo2    -FLSAIIGLAAQSVLANVFGGLFLSIVRPFKLGDHIVVNTWQFPVSFPSYPPKYFSRDFIEGSIYRGIVSDISINYTSIALES-----------GDVVKIPNNIMIQAAITLRH---------
Sso1    -FAGLVLGLAAQDVLANIFGGIMIVISRPYKVGDRVTVSTWQYGLLAPTYPPKFFSNDFLIP-GYTGTVTDISLLYTTIFTDD-----------QIPVKIPNSIMIQAAIFIHN---------
Sso4    -FIGIVIGFASQQVLGQAVAGLFLLVARPFKVNDNVNIVS-ED-----------------------GIVEDVSTLFTTILKAD-----------GTRVLIPNNMIIGNKIYLKQTEQQQKPQ-
Tac2    -VGALIIGIALQGIFSSIFSGFAVTSGGALKPGDVVNMQSWLFS------------------APITGEVMKISYLFSDIRTQN-----------GNIIKIPNSAFFGNTIFENLGKYDGFSYR
Tvo1    -VGALIIGIALQNIFSNIFSGFAVTSAGAIKPGEIVSMGSWLFG------------------SPITGEIVKVSYLFTDVKNSN-----------GRIIKVPNSAFLGNTIFERLSGESDFSYN
Sso2    -VGGIVIGLAVQTIAQNILSGILVTSSRTIRLNDAVSLISWIWG------------------NPIIGEISKISLLFTEVKTIN-----------GNVIKIPNSAFLGNTVFQKLESEHSLVYP
         . . ::*:* * :  . ..*: :    . . .: : : :                          * : .:*  :: :   .              : :**. :.   :  .          

V:
Bma     -GLGLAVGTAWGGLLAHFAAGVFMQVLRPFKVGDVISAG------------------------GVTGTVKELGLFGTTIVTAD-----------NVVTLVGNNKIFSDNIANYSATPTRRVD-
Bps     -GLGLAVGTAWGGLLAHFAAGVFMQVLRPFKVGDVISAG------------------------GVTGTVKELGLFGTTIVTAD-----------NVVTLVGNNKIFSDNIANYSATPTRRVD-
Pae3    -AVGLAIGMAWSGLLANLAAGGFIIVLRPFKVGDFICAG------------------------GVTGTVKEIGLFTTAINTPD-----------NVLTMVGNNKIFGDNIQNFTHNPFRRVE-
Vch2    -IAGVIIGFALQDTLSNFAAGMMLLIYRPFDVGDFVHAG------------------------GVDGKVSHMSLVNTTIRTFD-----------NQIIIVPNSKIWGDVIKNVTHERIRRVD-
Tma     -IGGLVIGLALQEPLANFFSGLFLLVSRAVKEGEALEAGG------------------------VSGTVEVVNLNHTVIRTWD-----------GRRVMIPNKAVWNDKIIHFWPSNVRRQE-
           *: :* *    *::: :* :: : *... *: : **                         * *.*. :.*  *.* * *           .   :: *. ::.* * :      ** : 

VI:
Eic     -AAGLAVGLALQGSLSNFAAGVLLVLFRPFRAGEVVDLG------------------------GVTGTVREVQIFSTTLATAD-----------NKVIVVPNGKIIAGNIINFSREPKRRID-
Eco2    -AAGLAVGLALQGSLSNLAAGVLLVMFRPFRAGEYVDLG------------------------GVAGTVLSVQIFSTTMRTAD-----------GKIIVIPNGKIIAGNIINFSREPVRRNE-
Bsp     -AAGMAIGLALQGSLSNFAAGVLLVTLRPLKTEEYVDLG------------------------SVSGTVLNIHIFYTTLRTLD-----------GKIVVVPNNKIISGNIINYSREPARRNE-
Vch1    -AAGLAVGLALQGSLSNFAAGVLIVAFRPFKSGDYVEIG------------------------GVAGSVDSIQIFQTVLKSPD-----------NKMVVVPNSAVIGGAITNYSRHETRRVD-
Pae2    -AAGLAIGLALQGSLANFAGGVLILLFRPFKVGDWIEAQ------------------------GVAGTVDSILIFHTVLRSGD-----------NKRIIVPNGALSNGTVTNYSAEPVRKVI-
Ssp1    -ASTLAIGLALQGSLANVAGGILLVLFNYFRVGERIEVA------------------------GIEGIVESIEILSTTICTYD-----------NRLVTIPNKQIIENNIINHVGKPERRID-
Mlo2    -AIGLAIGLALQGTLQNIAAGIMLLALRPFRIGESVEVG------------------------AISGSIEEIGLFATRLRTAD-----------GVYILAPNSTLWNQPVRNFSRNGVRRSD-
Xfa1    -ATGLAVGLALKDSLSNIAAGVMLIVLGPVRSGDHVVIA------------------------GQEGIIDEIRIFQTRLRTFD-----------QRIITLPNSTITTVPIINYSTLPTRRIE-
Hpy1    -TVGIAVALALKDYLSSIAGGIILIILHPFKKGDIIEIS------------------------GLEGKVEALNFFNTSLRLHD-----------GRLAVLPNRSVANSNIINSNNTACRRIE-
Nme1    -GAGLAVALSLKDQLSNFAAGALIILFRPFKVGDFIRVG------------------------GFEGYVREIKMVQTSLRTTD-----------NEEVVLPNSVVMGNSIVNRSTLPLCRAQ-
Ccr1    -AASLAIGLALQGALSNVAAGVMILLFRPYKVGDFIETA------------------------TRQGTVKSLDLLFTEIATPD-----------NVKVMIPNSKVFGDVILNYSTHRNRRVD-
            :*:.*:*:. * ..*.* ::: :   :  : :                              * :  : :. * :   *                 **  :    : *       :   

VII:
AefA_Eco-ALSVGLGFGLQEIFGNFVSGLIILFERPVRIGDTVTIG------------------------SFSGTVSKIRIRATTITDFD-----------RKEVIIPNKAFVTERLINWSLTDTTTRLV
Pch2    -ALSVGLGFGLQEIFANFVSGLIILFERPVRIGDTITIG------------------------TFSGSVSKIRIRATTITDFD-----------RKEVIIPNKAFVTERLINWSLSDTITRVL
Pmu     -ALSVGLGFGLQEIFANFVSGLIILFERPVRIGDVITIG------------------------EYSGTVSRIRIRSTTLIDFD-----------RKEVIVPNKAFVTERLVNWALNDSVTRVV
Pae1    -ALSVGLGFGLQAIFSNFVSGLIILFERPVRIGDVVTIG------------------------NLSGTVSRIRIRATTITDFD-----------RKEIIVPNQTFITGQLVNWSLSDTVTRVT
Eco3    -ALGVGLGFGLQEIFANFISGLIILFEKPIRIGDTVTIR------------------------DLTGSVTKINTRATTISDWD-----------RKEIIVPNKAFITEQFINWSLSDSVTRVV
Pch1    -ALGVGLGFGLQEIFANFISGLIILFEKPIRIGDTVTIR------------------------DLTGSVMRINTRATTISDWD-----------RKEIIVPNKAFITEQFINWSLSDSVTRVV
Hin     -ALSVGLGFGMQEIFANFVSGIILLFERPIRVGDVVTIN------------------------EVSGTVAKIRIRAITLIDFD-----------RKEVIVPNKSFVTGQVTNWALSNTMTRLV
Pae4    -ALSVGIGFGLQAIVQNFISGLILLTERPVKVGDWVSLG------------------------GVEGDIRRINVRATEIQMGD-----------RSTVIVPNSQFISQTVRNVTMGNALGVVG
Mlo1    -ALSLGIGFGLQNVVSNFVSGLILLAERPFKVGDWIVAG------------------------DVSGTVKKISVRATEIETFQ-----------RQSVILPNSNLINNAVGNWTHRNKLGRID
         **.:*:***:* :. **:**:*:* *:*.::** :                              * : :*  *:  :   :           *. :*:**. ::.  . * :  :    : 

VIII:
Ssp2    -TLGLGIGLGLQNVTRNFVSGVTLLVEQKVKIGDYIRFQN------------------------IQGYVREVSTRAVVVGLKD-----------GSKVILPSSLLIENQVINYHYETQTVRLT
Ssp3    -GLGIGIGFGLQELTRNLVSGLTIFGENKLKVGDLIEFNN------------------------HIGYIKEISIRSTIIRTFR-----------GSDLVVPNTDLTSNLVVNWNYENCSGRLE
Ccr2    -ALGVGVGLGLQGVIKDFASGVSLVFERLVAVGDFVELPNG-----------------------GRGVVHEIGPRATRIRTND-----------STDIIVPNSVLVNDQVINWTLRGTNRRLR
Cte     -TIGLGIGFGLQNIADNFFSGLIILLERPVKVGDRIQVG------------------------EINGDVVRIAIRSTTLLTND-----------NINIIIPNSEFVSKQVINWSHNDRSLRVS
Aae2    -ALGIGLGFGLQTIFNNYVSGFILLLSKNIKVGDYIEIEGKAGA------------AVGAGGDTIFGRVVSINILTTIVRTWD-----------NVEVAIPNSEFLSSKIVNYSMTNPIVRVR
Sme1    -AVGVGVGFGLQKVVSNFISGIIILLDKSIKPGDTITLG------------------------ETFGSIRDLRARFVSVITRD-----------GKEYLIPNEDFISQQVVNWSFSSDYVRID
          :*:*:*:*** :  :  **. :. .. :  ** : .                            * :  :    . :               . .  :*.  : .. ::*:       *: 
        1--------10--------20--------30--------40--------50--------60--------70--------80--------90--------100-------110-------120 
             8(G------TMS--------L)26


 











            

             8(G-------TMS-------F)26
        1--------10--------20--------30--------40--------50--------60--------70--------80--------90--------100-------110-------120
IX & X:
Pab     -ITGIVLGFSAQTVIANLISGIFMYFDKPLEIGDPVEVGE------------------------YSGIVHDIRVFSTRIRTWD-----------GLLVRIPNEKLFNSEIKNLAKYPARRVD-
Pho     -ITGIVLGFSAQTVISNLISGIFMYFDKPLEIGDPIEVAG------------------------YSGVVHDIRIFSTRIRTWD-----------GLLVRIPNEKLFNSEIKNLAKYPARRVD-
Afu     -ITGIVLGFASQSVVANLVSGIFLISEKPIKIGDQVNIDG------------------------VAGFVEDVNILSTIIRTYD-----------GLYVRIPNEKVFTSNITNYVAHIARRFE-
Ape2    -IVGIALGIASQTVASNLIAGVFLYLERPFKVGDPVIVGS------------------------IGGVVYDISILSSKILKWD-----------GVMARIPNEALFKSNVDVLNKSLARRVE-
Tpa     -IAGVALGFAAQTSVSNVISGLFVMTERAFRIQDVIEIDG------------------------IVGAVQSINLLSVALKTLD-----------GQYVRVPNETILKANLVNYSHCPHRRVK-
Ape1    -FAGLVLSLALQPLFSNFFSGLYLYGEKSLVIGDLISIGG------------------------FIGRVVEISTMSTRVRTLD-----------GEVVRIPNSRIINDYMVNYSKSAVRRLT-
Mth     -IAGVSVGFASRDIISNFISGMFILADKSFRVGDTIEVA------------------------GQRGRVRKVGFRTTTIETPE-----------AGMVTVPNSTFSKTAYVNYTAEDRRRVE-
Hsp1    -FAGIVLGMAARQTLGSVIAGLVLMFSRPFEIGDWVQVG------------------------DKQGIVTDITIVNTRLQTFD-----------GEYVMLPNDVVGSSEIVNRSRKGRLRVH-
Hsp2    -FLGIVIGTAARTTIGSLIAGLVLMVARPFEIGDWIALA------------------------DAEGTVTDITVVNTRVRNPS-----------GEEVVIPNENVLNATITNRTSLDRLRLS-
         : *: :. : :   ....:*: :   :.: : * : :                            * * .:   .  : . .           .  . :**. . .            *.  

XII & XIII:
Bha1    -LGGLAFALAAQDTIGNFFGGVIIVTEKPFSKGDWIQTP------------------------TVEGVVEDITFRSTRVRTFA-----------DSVVTVPNSTLASEPITNWSQMRKRRIT
Bsu1    -LGGLAFALAAKDTISNFFGGIIIITEKPFTIGDWVETS------------------------TVTGSVEDITFRSTRFRTAQ-----------GALVTVPNSTLSMEAITNWTRMTKRQIT
Mja1    -VGGLALALAMQDTIKNFIAGILILIDKPFSLGHWVKVK------------------------GAEGIVEEIGIRSTRIRTFD-----------YTLITIPNSELLDSAIENLTVRDRRRVL
Aae1    -LLGLAVSLAAKDTFENILSGLIILLDKPVKVGETVKVK------------------------DFMGSVEDIGLRSTKIRTFD-----------KSLVTIPNRDIVNNHVENFTRRNKRRVR
Mja2    -IGGLAVALASQNLVSNLIAGLIILTDKPFKIGNWITFS------------------------GGSGIVEDIGIRSTKIRATD-----------NSIIVVPNSKLIDEIIQNVPSKNKWKVS
Eco4    -IGGLAVGMAGKDILSNFFSGIMLYFDRPFSIGDWIRSPD----------------------RNIEGTVAEIGWRITKITTFD-----------NRPLYVPNSLFSSISVENPGRMTNRRIT
         : ***..:* :: . *::.*:::  ::*.. *. :                              * * :*  * *:. :                : :**  :    : *     . :: 

XIV:
Cje1    -IGGLAVALAAKDIIANFFASILLLFDNSFNQGDWVEVS------------------------GIEGTVVETGLRKTTIRTFD-----------NCLVFLPNSTIMGANIKNWSKRRMGRHVR
Hpy3    -IGGLAVALAVKDVLANFFASVILLLDNSFSQGDWIVCG------------------------EVEGTVVEMGLRRTTIRAFD-----------NALLSVPNSELAGKPIRNWSRRKVGRRIK
         *********.**::******::**:****.****:  .                         :****** ***:****:**           *.*: :*** : *  *:***:*::**:::

XV & XVI:
Cje2    -FASAGLAIAMKDMFMSMLGWCVIIFGGSFRVGDRVKVFQNDT--------------------TYIGDIIDISFLRITLYEELTLETYNKNRRSGRIIFIPNNYVFTNLLANYTHHGMKTVLD
Hpy2    -FASAGLAIAMKDLFMSLLGWFIILIGGSVHVGDRVRIAKGTD--------------------IFIGDVLDISMLHITILEDVTFTTYSNNRRAGRIIFVPNNYIFTTMFANYSHFGMKTVWD
Bsu3    -LISLILGFALQMPISSFIAWIYILARAPYRVGDRIRIGD------------------------AHGDVIDVSYLDTTLWEFGGEYLWTDHP-SGRIIKFPNSTVFDTPVFNYSWPLFPYVW-
Mja3    -LIGAAVTYALQKPILNFAGWIIILYTRTIKIGDRIFIKN-----------------------MGAGDVFDIDTQHIYLSELTTDTFEP--T--GRVLIIPNSYIFTASIENLTK-GSPYIWD
         : .  :  *::  : .: .*  *:   . ::***: : .                          **::*:.     : *             **:: .**. :*   . * :      :  

XVII:
Ath2    SQLLLVVFVFGNSCKTIFEAVIFVFVMHPFDVGDRCEIDG------------------------VQMIVEEMNILTTVFLRFD-----------NQKIVYPNSLLGTKPIANYYRSPDMQDA-
Ath6    SQLLLVAFVFGNSCKTIFEAIIFLFVMHPFDVGDRCEIDG------------------------VQLVVEEMNILTTVFLRYD-----------NQKIIYPNSVLGTKPIANYYRSPDMGDA-
Ath3    SQVVVVAFIFGNMCKIVFESIIYLFVIHPFDVGDRCEIDG------------------------VQMVVEEMNILTTVFLRFD-----------NQKVVYPNSLLWTKSIGNYYRSPDMGDG-
Ath4    SQVVLLAFMFGNSLKTVFESIIFLFIIHPYDVGDRLLIDT------------------------VEMVVEEMNILTTVFLRAD-----------NLKIVYPNILLWQKAIHNYNRSPDMGDE-
Ath7    SQVVLLAFIFGNTVKTVFESIIFLFIVHPYDVGDRCEIDS------------------------VQLVVEEMNILTTVFLRYD-----------NLKIMYPNSLLWQKSINNYYRSPDMGDA-
Ath5    TQLVALAFIIGSTCKNLFESIVFVFVMHPYDVGDRCVVDG------------------------VAMLVEEMNLLTTVFLKLN-----------NEKVYYPNAVLATKPISNYFRSPNMGET-
Spo2    TTLLGLSWLFSGSAQELLSSIIFVFVKHPYDVGDRVDVMINGT--------------------VTSAMVKEISIMSTEFRLLT-----------GKVIQAPNSLLNTLWILNMRRSDGIADP-
Spo1    TTLLSLSFVFSTSAQELMSSIIFLFSKHPFDISDVVIVNN------------------------IKYEVVSLSLLFTVFRTMG-----------GSTVQAPNSLLNTLFIENLRRSQPQSETI
        : :: : :::.   : ::.:::::*  **:*:.*   :                              * .:.:: * *               .  :  ** :*    * *  **    :  

XVIII:
Eco6    -AMAAVLMLVFKDPILGLVAGIQLSANDMLKLGDWLEMPKY----------------------GADGAVIDIGLTTVKVRNWD-----------NTITTIPTWSLVSDSFKNWSGMSASGGRR
Vch3    -AMTAVFMLVFKDPILGLVAGVQLSANKMLSVGDWLEMPKY----------------------GADGSVIDISLTTVKVQNWD-----------KTITTIPSYALISDSFKNWKGMQESGGRR
Pae6    -AMSAVLLLVYKDTLMSFVASVQLTSNDMLRVGDWIEMPQV----------------------GADGDVVDITLYTVKVQNFD-----------KTIVSVPTWRLMSESFKNWRGMQQSGGRR
Xfa2    -AMMAVLILVFQDTLLSLVASVTINSNDMVRVGDWIEMPQQ----------------------GADGDVIDIALHTIKVQNWD-----------KTITAIPIKRLITDSFKNWRGMHESGGRR
Rpr     -AAAALLTFVFKDTVLGLLASLQLTTQKIINIGDLVRVG------------------------EIEGIVEKITISVVTIRNFD-----------QSISTVPTYSILNSNVTNYRGITESGARR
         *  *:: :*::*.::.::*.: :.::.:: :** :.:                           :* * .* : .:.::*:*           ::* ::*   ::.....*: *:  **.**

XIX:
Vch4    FALLGVGLFAGWSLLSNVTAFLILFVQNQCRIGCWVRIVDG--------------------ANFIEGKIIDMALLNVELETLE-----------GNRVLYPNNLFIVRPVIVLQKAPEKAVKK
Ape3    AVLLAAILLATWDLLMNMAAYYAIIITRIVSRDEYIIMPN-----------------------GVRGWVRDIRPLFVIVETKY------------GVYHVPNSMMLRLGVLTKRERSYYRLTV
Nme2    -AVAAAVVVATKELIMCLSGSILRSATQQYSVGDYIEING------------------------LRGRVVDINLLNTLMMQVGPNPLVGQLA--GTTVSFPNSLLLSHPVRRDNILGDYVIHT
Vch5    -AIAVAIVVASKEIILCFTGSIQRASSRSFRIGDWIEVGS------------------------VCGEVIEHNLMATVIQEIDLHHGQYNYT--GKTATLPNSMFFSHPVKNLNFMKRYVFHN
         .:  . :.*  .::  .:.       .    . :: : .                        : * : :   : . :                     **.:::   *   .      .  

XX:
Sco3    -IIGIVAGVAAQSTLGNLFAGFQIAFGDMVRMGDTVVVDG------------------------EWGTVEEITLTYLSVRTWD-----------ERRITMPVSYFTSKPFENWSRGTPQMTGT
Ssp7    -TIAVALGFAFKDYISSIIAGVVALFEAPYRVGDRIQIG------------------------DHYGEVTGYGLRGICLQTPD-----------DNNVTIPHNKTWTEPISNANGGNLEAQVA
Dra1    -VVGLAVGFAAQDILANLISGVTLLLDRPFRIGDWVRIR------------------------DYEGQVHGLTLRTTRIMTRD-----------NEWVSIPNKDVAGATVVNLTAGGTLRLN-
          :.:. *.* :. :..:::*.   :    *:** : :                            * *    *    : * *           :. :::* .     .. * . *       
        1--------10--------20--------30--------40--------50--------60--------70--------80--------90--------100-------110-------120
              9(F-------TMS------L)26  

98 Proteins Total:

G(81%)-X(11)-G(93%)-D(85%)-X-[IV](91%)-X(30)-G(92%)-X-V(90%)-X(31)-P(96%)-N(86%)-X(9)-N(68%)
.            .      .         .              .        .            .      .           .
19           7      15        9              8        10           4      14          31

# Missing for each conserved residue







Multiple alignment of the most conserved portions of the twenty principal subfamilies of the MscS family.  Numbers of the clusters are the 
same as indicated in Figure 5 and Table 3.  Bolded residues are those well conserved in most subfamilies; conserved residues in each subfamily 
are presented below that group of aligned sequences.  *, fully conserved; :, only close conservative substitutions; ¥, more distant conservative 
substitutions. The pattern of conserved residues is provided at the bottom of the figure with the percent identities indicated in parentheses 
following the most conserved residues.  X = any residue; alternative residues at any one position are indicated in brackets (i.e., [I V]).
(Pivetti et al., 2003)